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Targeted Allele Detail
Symbol: Aqp2tm1(AQP2)Suc
Name: aquaporin 2; targeted mutation 1, Shinichi Uchida
MGI ID: MGI:3687866
Synonyms: AQP2(763-772 del)
Gene: Aqp2  Location: Chr15:99579056-99584545 bp, + strand  Genetic Position: Chr15, 56.13 cM
Germline Transmission:  Earliest citation of germline transmission: J:113716
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Aqp2tm1(AQP2)Suc expresses 1 gene
Mutation detailsThe C terminus was exchanged for that of the human AQP2 with a deletion of bp 763-772. A floxed lacZ-neo was included in the vector and subsequently removed via cre-mediated recombination. Western blot detected expression of a chimeric protein in mutant mice. (J:113716)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aqp2 Mutation:  13 strains or lines available
Original:  J:113716 Sohara E, et al., Pathogenesis and treatment of autosomal-dominant nephrogenic diabetes insipidus caused by an aquaporin 2 mutation. Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14217-22
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory