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Targeted Allele Detail
Symbol: Ightm1(Igh564)Tik
Name: immunoglobulin heavy chain complex; targeted mutation 1, Thereza Imanishi-Kari
MGI ID: MGI:3687305
Synonyms: IgH564
Gene: Igh  Location: unknown  Genetic Position: Chr12, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:113555
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Insertion
Ightm1(Igh564)Tik expresses 1 gene
Mutation detailsA floxed neomycine resistance gene, as well as the VDJ 564 region from a hybridoma derived from an autoimmune SWRxNZB mouse, replaced a segment of DNA including DQ52 and the entire JH region. Male chimeric mice were bred to C57BL/6 females. The resulting offspring were crossed with cre expressing transgenic mice in order to excise the neomycin resistance cassette. (personal communication)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igh Mutation:  33 strains or lines available
Original:  J:113555 Berland R, et al., Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice. Immunity. 2006 Sep;25(3):429-40
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory