Nlrp3^tm1Flv
Targeted Allele Detail

Summary

• Symbol: Nlrp3^tm1Flv
• Name: NLR family, pyrin domain containing 3; targeted mutation 1, Richard A Flavell
• MGI ID: MGI:3686871
• Synonyms: Cias1^-, cryopyrin, Nalp3^-, Nlrp3^-
• Gene: Nlrp3 Location: Chr11:59432395-59457781 bp, + strand Genetic Position: Chr11, 37.73 cM, cytoband B1.3
• Alliance: Nlrp3^tm1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113333
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-LacZ-MC1-neo cassette replaced exons 1 and 2. RT-PCR confirmed absence of transcript in mutant splenocytes. (J:113333)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nlrp3 Mutation: 61 strains or lines available

References

• Original: J:113333 Sutterwala FS, et al., Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity. 2006 Mar;24(3):317-27
• All: 187 reference(s)