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Pycardtm1Flv
Targeted Allele Detail
Nomenclature
Symbol: Pycardtm1Flv
Name: PYD and CARD domain containing; targeted mutation 1, Richard A Flavell
MGI ID: MGI:3686870
Synonyms: Asc-, Pycard-
Gene: Pycard  Location: Chr7:127991373-127993867 bp, - strand  Genetic Position: Chr7, 69.88 cM, cytoband F4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:113333
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2, 3 and part of exon 1, including the ATG, were replaced with an IRES-LacZ-MC1-neo cassette. RT-PCR confirmed absence of transcript in mutant splenocytes. (J:113333)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pycard Mutation:  5 strains or lines available
References
Original:  J:113333 Sutterwala FS, et al., Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity. 2006 Mar;24(3):317-27
All:  79 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory