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Notch1tm1Pst
Targeted Allele Detail
Nomenclature
Symbol: Notch1tm1Pst
Name: notch 1; targeted mutation 1, Pamela Stanley
MGI ID: MGI:3665446
Synonyms: Notch1-
Gene: Notch1  Location: Chr2:26457903-26516663 bp, - strand  Genetic Position: Chr2, 18.91 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:112097
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
    LoxP sites were inserted to flank exons 6-8. (J:112097)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Notch1 Mutation:  32 strains or lines available
References
Original:  J:112097 Stahl M, et al., Notch1-induced transformation of RKE-1 cells requires up-regulation of cyclin D1. Cancer Res. 2006 Aug 1;66(15):7562-70
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory