Tcra-J^tm1Kgwa
Targeted Allele Detail

Summary

• Symbol: Tcra-J^tm1Kgwa
• Name: T cell receptor alpha, joining region; targeted mutation 1, Osami Kanagawa
• MGI ID: MGI:3665411
• Synonyms: 2B4alphKI
• Gene: Tcra-J Location: unknown Genetic Position: Chr14, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50143
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A PGK-neo and a rearranged 2B4 TCR ValphaJalpha and Ig heavy chain enhancer (2B4-alpha IgHepsilon) to replace the J47-J50 region of the locus. (J:50143)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcra-J Mutation: 0 strains or lines available

References

• Original: J:50143 Wang F, et al., Rapid deletion of rearranged T cell antigen receptor (TCR) Valpha-Jalpha segment by secondary rearrangement in the thymus: role of continuous rearrangement of TCR alpha chain gene and positive selection in the T cell repertoire formation. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11834-9
• All: 3 reference(s)