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Pot1atm1Tdl
Targeted Allele Detail
Nomenclature
Symbol: Pot1atm1Tdl
Name: protection of telomeres 1A; targeted mutation 1, Titia de Lange
MGI ID: MGI:3665329
Synonyms: POT1aSTOP
Gene: Pot1a  Location: Chr6:25743940-25809277 bp, - strand  Genetic Position: Chr6, 11.65 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:112185
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert a floxed neo and an FRT-flanked puro-STOP cassette upstream of the third coding exon. A third loxP site was inserted downstream of the third coding exon. (J:112185)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pot1a Mutation:  7 strains or lines available
References
Original:  J:112185 Hockemeyer D, et al., Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres. Cell. 2006 Jul 14;126(1):63-77
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory