About   Help   FAQ
Targeted Allele Detail
Symbol: Rock1tm1Liao
Name: Rho-associated coiled-coil containing protein kinase 1; targeted mutation 1, James K Liao
MGI ID: MGI:3665285
Synonyms: Rock1-, Rock I-
Gene: Rock1  Location: Chr18:10064401-10181792 bp, - strand  Genetic Position: Chr18, 4.91 cM, cytoband A2
Germline Transmission:  Earliest citation of germline transmission: J:112242
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExon 1b was removed via cre-mediated recombination, resulting in a frame shift that created a stop codon in exon 1c, preventing translation of the functional protein. (J:112242)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rock1 Mutation:  28 strains or lines available
Original:  J:112242 Rikitake Y, et al., Rho-kinase mediates hyperglycemia-induced plasminogen activator inhibitor-1 expression in vascular endothelial cells. Circulation. 2005 Jun 21;111(24):3261-8
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory