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Rock1tm1Liao
Targeted Allele Detail
Nomenclature
Symbol: Rock1tm1Liao
Name: Rho-associated coiled-coil containing protein kinase 1; targeted mutation 1, James K Liao
MGI ID: MGI:3665285
Synonyms: Rock1-, Rock I-
Gene: Rock1  Location: Chr18:10064401-10181792 bp, - strand  Genetic Position: Chr18, 4.91 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:112242
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 1b was removed via cre-mediated recombination, resulting in a frame shift that created a stop codon in exon 1c, preventing translation of the functional protein. (J:112242)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rock1 Mutation:  26 strains or lines available
References
Original:  J:112242 Rikitake Y, et al., Rho-kinase mediates hyperglycemia-induced plasminogen activator inhibitor-1 expression in vascular endothelial cells. Circulation. 2005 Jun 21;111(24):3261-8
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory