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QTL Variant Detail
QTL variant: Nhdlq10PERA/EiJ
Name: non-HDL QTL 10; PERA/EiJ
MGI ID: MGI:3664915
QTL: Nhdlq10  Location: Chr16:7263744-7263853 bp  Genetic Position: Chr16, cM position of peak correlated region/allele: 3.43 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  PERA/EiJ
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased non-HDL cholesterol compared to I/LnJ. (J:112668)
Inheritance:    Not Specified
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures

Mapping and Phenotype information for this QTL, its variants and associated markers


To identify loci that influence lipo-protein cholesterol levels QTL mapping was performed on PERA/EiJ x I/LnJ and PERA/EiJ x DBA/2J intercrosses and in a combined data set from both crosses. Parental strain PERA/EiJ exhibits increased HDL cholesterol compared to I/LnJ and DBA/2J after 8 weeks on the high fat diet, while parental strain I/LnJ exhibits increased non-HDL cholesterol compared to PERA/EiJ and DBA/2J.

LOD scores for HDL cholesterol concentrations were considered significant when exceeding 2.9in each of the PERA intercrosses. A LOD score of 3.0 or better was the threshold for significance in the combined cross data when the cross was an additive covariate; 3.7 when the cross was an interactive covariate. The analysis of combined data from bothcrosses increased the detection power of the analysis.

Significant linkage to non-HDL cholesterol mapped to 4.0 cM near marker D16Mit122 in the (PERA/EiJ x I/LnJ)F2 cross, LOD=3.2, and is named Nhdlq10 (non-HDL QTL 8). The Nhdlq10 QTL interval spans 0cM- 14cM. The LOD increased to 3.9 in the combined cross data when cross was considered as an additive covariate. Higher levels of non-HDL cholesterol was associated with the allele from the PERA/EiJ strain at this locus.

Original:  J:112668 Wittenburg H, et al., QTL mapping for genetic determinants of lipoprotein cholesterol levels in combined crosses of inbred mouse strains. J Lipid Res. 2006 Aug;47(8):1780-90
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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