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Cd4del
Spontaneous Allele Detail
Nomenclature
Symbol: Cd4del
Name: CD4 antigen; deletion
MGI ID: MGI:3664575
Gene: Cd4  Location: Chr6:124864692-124888221 bp, - strand  Genetic Position: Chr6, 59.17 cM
Mutation
origin
Strain of Origin:  C57BR/cdJ
Mutation
description
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
 
Mutation detailsSequence analysis revealed that one thymine was substituted for the 14 bp at the junction between exon VIII and intron VIII. This results in the skipping of exon 8 in the expressed transcript, resulting in a deletion of the transmembrane domain and C-terminus of the encoded protein. Soluble Cd4 is detectable in the sera of mutant mice. (J:46692)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd4 Mutation:  65 strains or lines available
References
Original:  J:46692 Nagase H, et al., Novel mutant mice secreting soluble CD4 without expression of membrane-bound CD4. Eur J Immunol. 1998 Feb;28(2):403-12
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory