About   Help   FAQ
Gli2tm6Alj
Targeted Allele Detail
Nomenclature
Symbol: Gli2tm6Alj
Name: GLI-Kruppel family member GLI2; targeted mutation 6, Alexandra L Joyner
MGI ID: MGI:3664541
Synonyms: Gli2flox
Gene: Gli2  Location: Chr1:118834132-119053619 bp, - strand  Genetic Position: Chr1, 52.17 cM, cytoband E2-E4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:108507
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsTwo loxP sites were inserted flanking exons 7 and 8, which are upstream of the exons encoding the zinc fingers. A neo cassette flanked with Frt sites was also inserted upstream of exon 7 and then removed with Flp DNA recombinase. (J:108507)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 10 assay results
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gli2 Mutation:  92 strains or lines available
References
Original:  J:108507 Corrales JD, et al., The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation. Development. 2006 May;133(9):1811-21
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/10/2019
MGI 6.14
The Jackson Laboratory