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Ncr1tm1Oman
Targeted Allele Detail
Nomenclature
Symbol: Ncr1tm1Oman
Name: natural cytotoxicity triggering receptor 1; targeted mutation 1, Ofer Mandelboim
MGI ID: MGI:3664443
Synonyms: Ncr1gfp
Gene: Ncr1  Location: Chr7:4337724-4345164 bp, + strand  Genetic Position: Chr7, 2.5 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:112394
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace exons 5-7 with an IRES-GFP-PGK-neo. The neo was removed via cre-mediated recombination. Absence of endogenous transcript was confirmed by RT-PCR. Fluorescence is more intense after excision by Tg(Prm-cre)58Og (129/Sv background) or by Tg(Sp3-cre)93Knw (C57BL/6 background). When allele is made congenic on 129 or C57BL/6 background, immune system phenotype is not altered by removal of PGK-neo or by background. (J:112394)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ncr1 Mutation:  21 strains or lines available
References
Original:  J:112394 Gazit R, et al., Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1. Nat Immunol. 2006 May;7(5):517-23
All:  49 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory