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Tlr5tm1Aki
Targeted Allele Detail
Nomenclature
Symbol: Tlr5tm1Aki
Name: toll-like receptor 5; targeted mutation 1, Shizuo Akira
MGI ID: MGI:3664436
Synonyms: T5KO, Tlr5-
Gene: Tlr5  Location: Chr1:182954788-182976044 bp, + strand  Genetic Position: Chr1, 86.12 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:112391
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted into the coding exon. Northern blot failed to detect transcript in mutants. (J:112391)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tlr5 Mutation:  43 strains or lines available
References
Original:  J:112391 Uematsu S, et al., Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells. Nat Immunol. 2006 Aug;7(8):868-74
All:  48 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory