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Ccr2tm1Brv
Targeted Allele Detail
Nomenclature
Symbol: Ccr2tm1Brv
Name: chemokine (C-C motif) receptor 2; targeted mutation 1, Rodrigo Bravo
MGI ID: MGI:3664108
Synonyms: Ccr2-
Gene: Ccr2  Location: Chr9:124101918-124109140 bp, + strand  Genetic Position: Chr9, 75.05 cM, cytoband F
Ccr2tm1Brv/Ccr2tm1Brv mice are unable to clear Listeria monocytogenes infection

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:111517
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert a lacZ-neo cassette into the coding sequence. Immunoprecipitation analysis demonstrated lack of expression in mutants. (J:111517)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccr2 Mutation:  23 strains or lines available
References
Original:  J:111517 Kurihara T, et al., Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor. J Exp Med. 1997 Nov 17;186(10):1757-62
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory