Elavl4^tm1Okn
Targeted Allele Detail

Summary

• Symbol: Elavl4^tm1Okn
• Name: ELAV like RNA binding protein 4; targeted mutation 1, Hideyuki Okano
• MGI ID: MGI:3664094
• Synonyms: HuD^-
• Gene: Elavl4 Location: Chr4:110060919-110209106 bp, - strand Genetic Position: Chr4, 51.42 cM
• Alliance: Elavl4^tm1Okn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97282
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1 kb fragment including the exon containing the initiation site was replaced with a PGK-neo cassette via homologous recombination. RT-PCR analysis of adult brain and immunoblot analysis of adult brain and liver confirmed the absence of message and protein in homozygotes. (J:97282)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Elavl4 Mutation: 34 strains or lines available

References

• Original: J:97282 Akamatsu W, et al., The RNA-binding protein HuD regulates neuronal cell identity and maturation. Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4625-30
• All: 10 reference(s)