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Metap2tm1.2Ccr
Targeted Allele Detail
Nomenclature
Symbol: Metap2tm1.2Ccr
Name: methionine aminopeptidase 2; targeted mutation 1.2, Craig M Crews
MGI ID: MGI:3663890
Synonyms: MAP2D
Gene: Metap2  Location: Chr10:93858489-93897093 bp, - strand  Genetic Position: Chr10, 48.69 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:111701
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsTwo loxP sites were inserted into the 5' UTR and the first intron via homologous recombination. A neomycin resistance gene flanked by two frt sequences was also introduced into the intron. Floxed mice with the neomycin resistance gene were crossed with Tg(ACTB-cre)2Mrt mice to remove the floxed exon 1. (J:111701)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Metap2 Mutation:  27 strains or lines available
References
Original:  J:111701 Yeh JR, et al., Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10379-84
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory