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Targeted Allele Detail
Symbol: Pde10atm1Pfi
Name: phosphodiesterase 10A; targeted mutation 1, Pfizer, Ltd
MGI ID: MGI:3663426
Synonyms: Pde10-, Pde10atm1Jasi
Gene: Pde10a  Location: Chr17:8525372-8986648 bp, + strand  Genetic Position: Chr17, 4.96 cM
Germline Transmission:  Earliest citation of germline transmission: J:111662
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  DBA/1LacJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neo vector was designed to replace exons 14-16, corresponding to bases 1499-1861 of the coding region. Sequence analysis revealed that the neo cassette was spliced out. The resulting transcript encoded an in-frame deletion of 126 amino acids at the N-terminus of the catalytic domain. This terminus contained one of the two divalent zinc binding sites. Since the deletion was in-frame, a mutant protein of approximately 75 kDa could be produced. (J:111662)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pde10a Mutation:  34 strains or lines available
Original:  J:111662 Siuciak JA, et al., Genetic deletion of the striatum-enriched phosphodiesterase PDE10A: evidence for altered striatal function. Neuropharmacology. 2006 Aug;51(2):374-85
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory