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Targeted Allele Detail
Symbol: Scnn1gtm1Bhk
Name: sodium channel, nonvoltage-gated 1 gamma; targeted mutation 1, Beverly H Koller
MGI ID: MGI:3663382
Synonyms: gammaENaC-
Gene: Scnn1g  Location: Chr7:121734479-121768475 bp, + strand  Genetic Position: Chr7, 65.07 cM
Germline Transmission:  Earliest citation of germline transmission: J:50528
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced the exon with the putative start codon. Northern blot analysis on RNA derived from kidney demonstrated that no detectable protein is expressed from this allele. (J:50528)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scnn1g Mutation:  3 strains or lines available
Original:  J:50528 Barker PM, et al., Role of gammaENaC subunit in lung liquid clearance and electrolyte balance in newborn mice. Insights into perinatal adaptation and pseudohypoaldosteronism. J Clin Invest. 1998 Oct 15;102(8):1634-40
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory