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Targeted Allele Detail
Symbol: Ptpn1tm2Bbk
Name: protein tyrosine phosphatase, non-receptor type 1; targeted mutation 2, Barbara B Kahn
MGI ID: MGI:3663370
Synonyms: PTP-1Bfl, Ptpnflox
Gene: Ptpn1  Location: Chr2:167932057-167979385 bp, + strand  Genetic Position: Chr2, 87.99 cM, cytoband H3
Germline Transmission:  Earliest citation of germline transmission: J:111969
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA targeting vector was designed to flank exons 6-8 of the locus. This sequence encompasses the active site and surrounding parts of the catalytic domain. A floxed neo was removed via cre mediated excision. (J:111969)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptpn1 Mutation:  30 strains or lines available
Original:  J:111969 Bence KK, et al., Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med. 2006 Aug;12(8):917-24
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory