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Igfbp3tm1Jep
Targeted Allele Detail
Nomenclature
Symbol: Igfbp3tm1Jep
Name: insulin-like growth factor binding protein 3; targeted mutation 1, John E Pintar
MGI ID: MGI:3663361
Synonyms: BP3KO
Gene: Igfbp3  Location: Chr11:7206086-7213923 bp, - strand  Genetic Position: Chr11, 4.75 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:112029
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of exon 1, including the translation start site and signal peptide, was replaced by a neomycin resistance cassette. Western blot failed to detect protein in mutants. (J:112029)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Igfbp3 Mutation:  7 strains or lines available
References
Original:  J:112029 Ning Y, et al., Diminished growth and enhanced glucose metabolism in triple knockout mice containing mutations of insulin-like growth factor binding protein-3, -4, and -5. Mol Endocrinol. 2006 Sep;20(9):2173-86
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory