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Adam21tm1Dgen
Targeted Allele Detail
Nomenclature
Symbol: Adam21tm1Dgen
Name: a disintegrin and metallopeptidase domain 21; targeted mutation 1, Deltagen
MGI ID: MGI:3663320
Gene: Adam21  Location: Chr12:81558584-81568474 bp, - strand  Genetic Position: Chr12, 37.79 cM
Mutation
origin
Mutant Cell Line:  7990
Germline Transmission:  Earliest citation of germline transmission: J:101679
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Project Collection: Deltagen
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details A LacZ-neomycin cassette was inserted into the gene so that the endogenous gene promoter drives expression of beta-galactosidase. RNA transcripts were detected in most tissues tested but not in heart, thymus, bone marrow, and urinary bladder. LacZ expression was detected in kidney and testis tissues. No LacZ expression was detected in nervous, cardiovascular, hematopoietic tissue, the respiratory system, liver, pancreas, urinary bladder, thyroid, pituitary, adrenal, prostate glands, skeletal muscle, skin, ovary, uterus, or cervix. (J:101679)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 31 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adam21 Mutation:  15 strains or lines available
Notes
See also, data as provided by Deltagen, Inc.
References
Original:  J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory