About   Help   FAQ
Tasp1tm1.1Jjdh
Targeted Allele Detail
Summary
Symbol: Tasp1tm1.1Jjdh
Name: taspase, threonine aspartase 1; targeted mutation 1.1, James J Hsieh
MGI ID: MGI:3663289
Synonyms: Tasp1-
Gene: Tasp1  Location: Chr2:139675400-139908725 bp, - strand  Genetic Position: Chr2, 69.2 cM
Alliance: Tasp1tm1.1Jjdh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:112159
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 9 and a floxed PGK neo cassette was inserted into intron 9. Successfully targeted ES cells were subsequently transiently transfected with CMV-cre to excise both exon9 9 and the PGKneo. Protein was not detected in mutant MEFs. (J:112159)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 24 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 13 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tasp1 Mutation:  38 strains or lines available
References
Original:  J:112159 Takeda S, et al., Proteolysis of MLL family proteins is essential for Taspase1-orchestrated cell cycle progression. Genes Dev. 2006 Sep 1;20(17):2397-409
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory