Slc40a1^ffe
Chemically induced Allele Detail

Summary

• Symbol: Slc40a1^ffe
• Name: solute carrier family 40 (iron-regulated transporter), member 1; flatiron
• MGI ID: MGI:3662903
• Synonyms: ffe^H32R, Fpn^ffe
• Gene: Slc40a1 Location: Chr1:45947228-45965683 bp, - strand Genetic Position: Chr1, 23.96 cM, cytoband B
• Alliance: Slc40a1^ffe page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This allele contains an A to G transition at position 95 in the coding sequence, resulting in an H32R substitution in the signal sequence. (J:118592)
• Inheritance: Dominant

Disease models

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc40a1 Mutation: 53 strains or lines available

References

• Original: J:118592 Zohn IE, et al., The flatiron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease. Blood. 2007 May 15;109(10):4171-80
• All: 9 reference(s)