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Targeted Allele Detail
Symbol: Mkl1tm1Eno
Name: MKL (megakaryoblastic leukemia)/myocardin-like 1; targeted mutation 1, Eric N Olson
MGI ID: MGI:3662669
Gene: Mkl1  Location: Chr15:81012281-81190757 bp, - strand  Genetic Position: Chr15, 37.98 cM
Germline Transmission:  Earliest citation of germline transmission: J:111412
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA vector was designed to delete a part of exon 9 and all of exon 10, which encode the basic, glutamine-rich and SAP domains. A lacZ was fused in frame with exon 9 and a neo cassette. RT-PCR demonstrated that the correct exons were deleted and that exon 8 was spliced to exon 12, thereby deleting the lacZ-neo cassette. The resulting truncated protein would be nonfunctional. (J:111412)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mkl1 Mutation:  7 strains or lines available
Original:  J:111412 Li S, et al., Requirement of a myocardin-related transcription factor for development of mammary myoepithelial cells. Mol Cell Biol. 2006 Aug;26(15):5797-808
All:  10 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
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