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Tg(GFAP-cre)1Kdmc
Transgene Detail
Nomenclature
Symbol: Tg(GFAP-cre)1Kdmc
Name: transgene insertion 1, Ken D McCarthy
MGI ID: MGI:3655847
Synonyms: GFAP-cre
Transgene: Tg(GFAP-cre)1Kdmc  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6 x C3H
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsA human GFAP promoter was used to drive expression of Cre recombinase, with an intron and polyadenylation signals from the mouse protamine-1 gene. The promoter-cre fragment was surrounded by four copies of a genomic insulator. Cre recombinase expression is restricted to GFAP-positive astrocytes in brain; neurons and oligodendrocytes do not express the Cre protein. (J:108621)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: GFAP     Summary of all recombinase alleles driven by GFAP.
 

Phenotypes
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Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:108621 Casper KB, et al., GFAP-positive progenitor cells produce neurons and oligodendrocytes throughout the CNS. Mol Cell Neurosci. 2006 Apr;31(4):676-84
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory