About   Help   FAQ
Targeted Allele Detail
Symbol: Ttntm1.1Her
Name: titin; targeted mutation 1.1, Joachim Herz
MGI ID: MGI:3654306
Gene: Ttn  Location: Chr2:76703980-76982547 bp, - strand  Genetic Position: Chr2, 45.13 cM, cytoband D
Ttntm1.1Her/Ttntm1.1Her embryos fail to thrive after E9

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:111284
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExons 358 (MEx1) and 359 (MEx2) were removed by Cre mediated recombination. In situ hybridization analysis confirms the expression of a truncated protein lacking the kinase domain in homozygous embryos. (J:81993, J:111284)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ttn Mutation:  782 strains or lines available
Original:  J:111284 Weinert S, et al., M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere. J Cell Biol. 2006 May 22;173(4):559-70
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory