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Ttntm1.1Her
Targeted Allele Detail
Nomenclature
Symbol: Ttntm1.1Her
Name: titin; targeted mutation 1.1, Joachim Herz
MGI ID: MGI:3654306
Gene: Ttn  Location: Chr2:76703980-76982547 bp, - strand  Genetic Position: Chr2, 45.13 cM, cytoband D
Ttntm1.1Her/Ttntm1.1Her embryos fail to thrive after E9

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:111284
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExons 358 (MEx1) and 359 (MEx2) were removed by Cre mediated recombination. In situ hybridization analysis confirms the expression of a truncated protein lacking the kinase domain in homozygous embryos. (J:81993, J:111284)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ttn Mutation:  604 strains or lines available
References
Original:  J:111284 Weinert S, et al., M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere. J Cell Biol. 2006 May 22;173(4):559-70
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory