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Targeted Allele Detail
Symbol: Tiraptm1Aki
Name: toll-interleukin 1 receptor (TIR) domain-containing adaptor protein; targeted mutation 1, Shizuo Akira
MGI ID: MGI:3654146
Synonyms: Mal-, Tirap-
Gene: Tirap  Location: Chr9:35184551-35200291 bp, - strand  Genetic Position: Chr9, 19.99 cM, cytoband A5.3
Germline Transmission:  Earliest citation of germline transmission: J:111205
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to replace the two exons encoding the TIR domain with a neomycin resistance gene. The insertion created a stop codon in the N-terminal portion of the locus. Immunoblot confirmed that disruption of the locus abolished the expression of protein. (J:111205)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tirap Mutation:  11 strains or lines available
Original:  J:111205 Yamamoto M, et al., Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature. 2002 Nov 21;420(6913):324-9
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory