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Targeted Allele Detail
Symbol: Irak1tm1Wpfl
Name: interleukin-1 receptor-associated kinase 1; targeted mutation 1, Wai-Ping Fung-Leung
MGI ID: MGI:3654141
Gene: Irak1  Location: ChrX:74013914-74023918 bp, - strand  Genetic Position: ChrX, 37.61 cM
Germline Transmission:  Earliest citation of germline transmission: J:110860
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was used to replace exons 5-7 with a neomycin resistance gene. Protein was not detected in mutant MEFs. (J:110860)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Irak1 Mutation:  8 strains or lines available
Original:  J:110860 Kanakaraj P, et al., Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production. J Exp Med. 1998 Jun 15;187(12):2073-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory