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Xrcc2tm1Pmc
Targeted Allele Detail
Nomenclature
Symbol: Xrcc2tm1Pmc
Name: X-ray repair complementing defective repair in Chinese hamster cells 2; targeted mutation 1, Peter J McKinnon
MGI ID: MGI:3654106
Synonyms: Xrcc2-
Gene: Xrcc2  Location: Chr5:25689812-25705825 bp, - strand  Genetic Position: Chr5, 12.35 cM, cytoband A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:111068
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neo cassette was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Cre-mediated recombination removed exon 3 (75% of the open reading frame). RT-PCR failed to detect transcript in mutant mouse embryonic fibroblasts. (J:111068)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Xrcc2 Mutation:  6 strains or lines available
Notes
This allele was generated from Xrcc2tm2Pmc.

References
Original:  J:111068 Orii KE, et al., Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10017-22
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory