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Targeted Allele Detail
Symbol: Csf2rbtm1Clsc
Name: colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); targeted mutation 1, Clare L Scott
MGI ID: MGI:3653883
Synonyms: betac null, Csf-2-, Csf2rb1tm1Clsc
Gene: Csf2rb  Location: Chr15:78325990-78351000 bp, + strand  Genetic Position: Chr15, 37.36 cM
Germline Transmission:  Earliest citation of germline transmission: J:109889
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsES cells already containing the Csf2rb2tm2Cgb mutation were targeted a second time with a vector containing a hygromycin resistance-gene in exon 7 and a TK cassette at the upstream end of the construct. Three different ES cell lines were used to create chimeric mice. (J:109889)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Csf2rb Mutation:  10 strains or lines available
This allele was created on a chromosome already carrying the Csf2rb2tm2Cgb allele. Mice homozygous for both alleles are referred to as betac/betaIL3 null mice.
Original:  J:109889 Scott CL, et al., Reassessment of interactions between hematopoietic receptors using common beta-chain and interleukin-3-specific receptor beta-chain-null cells: no evidence of functional interactions with receptors for erythropoietin, granulocyte colony-stimulating factor, or stem cell factor. Blood. 2000 Aug 15;96(4):1588-90
All:  15 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
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