Aqp2^tm1Bxy
Targeted Allele Detail

Summary

• Symbol: Aqp2^tm1Bxy
• Name: aquaporin 2; targeted mutation 1, Baoxue Yang
• MGI ID: MGI:3653759
• Synonyms: Aqp2^flox
• Gene: Aqp2 Location: Chr15:99476937-99482426 bp, + strand Genetic Position: Chr15, 56.13 cM
• Alliance: Aqp2^tm1Bxy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110648
• Parent Cell Line: CB1-4 (ES Cell)
• Strain of Origin: C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to flank exon 2 with loxP sites. A PGK-neo was inserted with the vector such that it would be removed with exon 2 upon cre recombinase expression. (J:110648)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aqp2 Mutation: 17 strains or lines available

References

• Original: J:110648 Yang B, et al., Mouse model of inducible nephrogenic diabetes insipidus produced by floxed aquaporin-2 gene deletion. Am J Physiol Renal Physiol. 2006 Aug;291(2):F465-72
• All: 2 reference(s)