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Targeted Allele Detail
Symbol: Aqp2tm1Bxy
Name: aquaporin 2; targeted mutation 1, Baoxue Yang
MGI ID: MGI:3653759
Synonyms: Aqp2flox
Gene: Aqp2  Location: Chr15:99579056-99584545 bp, + strand  Genetic Position: Chr15, 56.13 cM
Germline Transmission:  Earliest citation of germline transmission: J:110648
Parent Cell Line:  CB1-4 (ES Cell)
Strain of Origin:  C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA targeting vector was designed to flank exon 2 with loxP sites. A PGK-neo was inserted with the vector such that it would be removed with exon 2 upon cre recombinase expression. (J:110648)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aqp2 Mutation:  13 strains or lines available
Original:  J:110648 Yang B, et al., Mouse model of inducible nephrogenic diabetes insipidus produced by floxed aquaporin-2 gene deletion. Am J Physiol Renal Physiol. 2006 Aug;291(2):F465-72
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory