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Map2tm1Zhku
Targeted Allele Detail
Nomenclature
Symbol: Map2tm1Zhku
Name: microtubule-associated protein 2; targeted mutation 2, Z Khuchua
MGI ID: MGI:3653757
Synonyms: delta1-158
Gene: Map2  Location: Chr1:66175273-66442583 bp, + strand  Genetic Position: Chr1, 33.49 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:110727
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace exon 2 with a neomycin resistance gene. This exon was 285-bp long and contained the translation start site and the RII bonding site. Mutants would putatively generate a truncated protein, translated from the next in-frame ATG site in exon 3. Western blot demonstrated that mutants expressed more Mtap2 antigen than wild-type animals. Transcript levels were also increased, suggesting that some modulating regulatory elements are present within the targeted sequence deleted from the locus. (J:110727)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Map2 Mutation:  37 strains or lines available
References
Original:  J:110727 Khuchua Z, et al., Deletion of the N-terminus of murine map2 by gene targeting disrupts hippocampal ca1 neuron architecture and alters contextual memory. Neuroscience. 2003;119(1):101-11
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory