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Kcnd2tm1Jmn
Targeted Allele Detail
Nomenclature
Symbol: Kcnd2tm1Jmn
Name: potassium voltage-gated channel, Shal-related family, member 2; targeted mutation 1, Jeanne M Nerbonne
MGI ID: MGI:3653698
Synonyms: Kv4.2-
Gene: Kcnd2  Location: Chr6:21215503-21729805 bp, + strand  Genetic Position: Chr6, 8.49 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:111318
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace all of exon 1 with a neomycin resistance gene. Northern blot analysis failed to detect transcript in mutant brain, heart or liver samples. Western blot failed to detect protein in mutant hearts. (J:111318)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kcnd2 Mutation:  14 strains or lines available
References
Original:  J:111318 Guo W, et al., Targeted deletion of Kv4.2 eliminates I(to,f) and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunction. Circ Res. 2005 Dec 9;97(12):1342-50
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory