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Targeted Allele Detail
Symbol: Kcnd2tm1Jmn
Name: potassium voltage-gated channel, Shal-related family, member 2; targeted mutation 1, Jeanne M Nerbonne
MGI ID: MGI:3653698
Synonyms: Kv4.2-
Gene: Kcnd2  Location: Chr6:21215503-21729805 bp, + strand  Genetic Position: Chr6, 8.49 cM
Germline Transmission:  Earliest citation of germline transmission: J:111318
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to replace all of exon 1 with a neomycin resistance gene. Northern blot analysis failed to detect transcript in mutant brain, heart or liver samples. Western blot failed to detect protein in mutant hearts. (J:111318)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kcnd2 Mutation:  17 strains or lines available
Original:  J:111318 Guo W, et al., Targeted deletion of Kv4.2 eliminates I(to,f) and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunction. Circ Res. 2005 Dec 9;97(12):1342-50
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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