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Targeted Allele Detail
Symbol: Erap1tm1Iay
Name: endoplasmic reticulum aminopeptidase 1; targeted mutation 1, Ian A York
MGI ID: MGI:3653695
Gene: Erap1  Location: Chr13:74639624-74692537 bp, + strand  Genetic Position: Chr13, 40.48 cM, cytoband C1
Germline Transmission:  Earliest citation of germline transmission: J:111047
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExons 5 and 6 were removed via cre-mediated recombination, resulting in a frame shift that would lead to early termination of the exon 4 exon 7 fusion. The protein if expressed would not be enzymatically active as the active site is in exon 5. (J:111047)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Erap1 Mutation:  39 strains or lines available
Original:  J:111047 York IA, et al., Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9202-7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory