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Tg(tetO-CDK5R1/GFP)337Lht
Transgene Detail
Nomenclature
Symbol: Tg(tetO-CDK5R1/GFP)337Lht
Name: transgene insertion 337, Li-Huei Tsai
MGI ID: MGI:3653679
Synonyms: CK-p25 Tg, p25(337), p25-CK, p25-GFP, tetO-p25-GFP, Tg(tetO-p25/GFP)33Lth
Transgene: Tg(tetO-CDK5R1/GFP)337Lht  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6J
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Tg(tetO-CDK5R1/GFP)337Lht expresses 1 gene
 
Mutation detailsThe transgene expresses the carboxy-terminal proteolytic fragment (p25) of human cyclin-dependent kinase 5, regulatory subunit 1, bearing a carboxy-terminal green fluorescent protein (GFP) tag, under control of the tetracycline operator. The purpose of the GFP tag is to differentiate immunologically the transgene-encoded p25 from the endogenous p35 protein. (J:104240)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:104240 Cruz JC, et al., Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron. 2003 Oct 30;40(3):471-83
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory