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Kltm2Yin
Targeted Allele Detail
Nomenclature
Symbol: Kltm2Yin
Name: klotho; targeted mutation 2, Yo-ichi Nabeshima
MGI ID: MGI:3653671
Synonyms: kl-geo
Gene: Kl  Location: Chr5:150952607-150993817 bp, + strand  Genetic Position: Chr5, 89.77 cM, cytoband G3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:102218
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 681 bp fragment of exon 1 was replaced with a lacZ-neomycin fusion gene (betageo) and a floxed PGK-neo cassette. The floxed neo was removed by cre mediated recombination. LacZ expression is seen in a pattern similar to expression of the endogenous gene. Western blot analysis confirmed the absence of protein in homozygotes (J:102218)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kl Mutation:  36 strains or lines available
References
Original:  J:102218 Takeshita K, et al., Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression. Circulation. 2004 Apr 13;109(14):1776-82
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory