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Nkx2-1tm2Shk
Targeted Allele Detail
Nomenclature
Symbol: Nkx2-1tm2Shk
Name: NK2 homeobox 1; targeted mutation 2, Shioko Kimura
MGI ID: MGI:3653645
Synonyms: Nkz2-1F, T/ebp(fl)
Gene: Nkx2-1  Location: Chr12:56531958-56536908 bp, - strand  Genetic Position: Chr12, 24.42 cM, cytoband C1-C3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:111027
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to flank exon 2 and insert a floxed neo cassette. The neo was subsequently removed via cre-mediated recombination. (J:111027)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx2-1 Mutation:  5 strains or lines available
References
Original:  J:111027 Kusakabe T, et al., Thyroid-specific enhancer-binding protein/NKX2.1 is required for the maintenance of ordered architecture and function of the differentiated thyroid. Mol Endocrinol. 2006 Aug;20(8):1796-809
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory