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Zfp423tm1.2Ngc
Targeted Allele Detail
Summary
Symbol: Zfp423tm1.2Ngc
Name: zinc finger protein 423; targeted mutation 1.2, Neal G Copeland
MGI ID: MGI:3653506
Gene: Zfp423  Location: Chr8:88388438-88686223 bp, - strand  Genetic Position: Chr8, 42.29 cM, cytoband C4
Alliance: Zfp423tm1.2Ngc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:111316
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA single loxP sites was inserted just 5' of exon 4. Then an Frt flanked neomycin selection cassette followed by a second loxP site was inserted 3' of exon 4. Mice containing this targeted mutation were then crossed with transgenic mice expressing cre recombinase under the control of beta Actin. Both the neomycin selection cassette and exon 4 are deleted in the resulting mice. Northern blot analysis demonstrated the absence of full length mRNA. A weak band of a size appropriate for an exon 4 deleted mRNA is observed. (J:111316)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zfp423 Mutation:  274 strains or lines available
References
Original:  J:111316 Warming S, et al., Zfp423 is required for normal cerebellar development. Mol Cell Biol. 2006 Sep;26(18):6913-22
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory