About   Help   FAQ
Targeted Allele Detail
Symbol: Myh6tm1Rbns
Name: myosin, heavy polypeptide 6, cardiac muscle, alpha; targeted mutation 1, Jeffrey Robbins
MGI ID: MGI:3652543
Synonyms: alpha-MyHC-
Gene: Myh6  Location: Chr14:54941981-54966927 bp, - strand  Genetic Position: Chr14, 28.01 cM
Fibrotic lesions in Myh6tm1Rbns/Myh6+ hearts

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:36089
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neo-pA cassette replaced the 5' UTR, the start sites of transcription and translation and the first 3 exons of the locus. (J:36089)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myh6 Mutation:  75 strains or lines available
Original:  J:36089 Jones WK, et al., Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart. J Clin Invest. 1996 Oct 15;98(8):1906-17
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.12
The Jackson Laboratory