Serp1^tm1Hori
Targeted Allele Detail

Summary

• Symbol: Serp1^tm1Hori
• Name: stress-associated endoplasmic reticulum protein 1; targeted mutation 1, Osamu Hori
• MGI ID: MGI:3652355
• Synonyms: Serp1^-
• Gene: Serp1 Location: Chr3:58429390-58433305 bp, - strand Genetic Position: Chr3, 28.58 cM
• Alliance: Serp1^tm1Hori page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109619
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: A neomycin resistance gene replaced exon 1, containing the ATG. Western blot confirmed absence of protein in mutant pancreas samples. (J:109619)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Serp1 Mutation: 5 strains or lines available

References

• Original: J:109619 Hori O, et al., Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum (ER) translocation sites, leads to ER stress. Mol Cell Biol. 2006 Jun;26(11):4257-67
• All: 1 reference(s)