Rcan1^tm1Jmol
Targeted Allele Detail

Summary

• Symbol: Rcan1^tm1Jmol
• Name: regulator of calcineurin 1; targeted mutation 1, Jeffery D Molkentin
• MGI ID: MGI:3641540
• Synonyms: mcip1^-
• Gene: Rcan1 Location: Chr16:92188839-92263057 bp, - strand Genetic Position: Chr16, 53.6 cM
• Alliance: Rcan1^tm1Jmol page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109586
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 5 and 6 were replaced with a neomycin resistance gene via homologous recombination. Wesetern blot confirmed absence of protein in mutant heart, skeletal muscle and brain. (J:109586)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rcan1 Mutation: 24 strains or lines available

References

• Original: J:109586 Sanna B, et al., Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7327-32
• All: 7 reference(s)