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Hif1atm1Kats
Targeted Allele Detail
Nomenclature
Symbol: Hif1atm1Kats
Name: hypoxia inducible factor 1, alpha subunit; targeted mutation 1, Dorthe M Katschinski
MGI ID: MGI:3641209
Synonyms: HIF1aI.1-
Gene: Hif1a  Location: Chr12:73948149-73994304 bp, + strand  Genetic Position: Chr12, 31.99 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:110340
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Modified isoform(s))
Mutation:    Insertion
 
Mutation detailsA floxed neo cassette was inserted downstream of the testis specific exon I.1 and an additional loxP site was introduced upstream of exon I.1. by homologous recombination. Cre mediated recombination removed the neo cassette and exon I.1. Expression of the ubiqutous isoform using exon I.2 was intact. (J:110340, J:117857)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hif1a Mutation:  37 strains or lines available
References
Original:  J:110340 Hagele S, et al., TSGA10 prevents nuclear localization of the hypoxia-inducible factor (HIF)-1alpha. FEBS Lett. 2006 Jun 26;580(15):3731-8
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory