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Jchaintm3Tl
Targeted Allele Detail
Nomenclature
Symbol: Jchaintm3Tl
Name: immunoglobulin joining chain; targeted mutation 3, Tomas Leanderson
MGI ID: MGI:3641196
Synonyms: Igjtm2Tl, J-
Gene: Jchain  Location: Chr5:88519809-88527891 bp, - strand  Genetic Position: Chr5, 43.7 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:49168
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Deletion, Insertion
  Jchaintm3Tl involves 1 genes/genome features (Jchain) View all
 
Mutation detailsA construct was designed to replace the first exon with the DTA gene followed by a neomycin resistance cassette flanked by loxP sites. Northern blot failed to detect transcript in mutants. (J:49168)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Jchain Mutation:  14 strains or lines available
References
Original:  J:49168 Erlandsson L, et al., Mice with an inactivated joining chain locus have perturbed IgM secretion. Eur J Immunol. 1998 Aug;28(8):2355-65
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory