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Sh2d1b1tm1Vei
Targeted Allele Detail
Nomenclature
Symbol: Sh2d1b1tm1Vei
Name: SH2 domain containing 1B1; targeted mutation 1, Andre Veillette
MGI ID: MGI:3641174
Synonyms: EAT-2-deficient, Sh2d1b-/-
Gene: Sh2d1b1  Location: Chr1:170277320-170286769 bp, + strand  Genetic Position: Chr1, 76.84 cM, cytoband H2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:110195
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
    A targeting construct disrupted exon 2 of the gene creating a null allele. (J:110195)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sh2d1b1 Mutation:  2 strains or lines available
References
Original:  J:110195 Roncagalli R, et al., Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor. Nat Immunol. 2005 Oct;6(10):1002-10
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory