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Targeted Allele Detail
Symbol: Itpr2tm1.1Chen
Name: inositol 1,4,5-triphosphate receptor 2; targeted mutation 1.1, Ju Chen
MGI ID: MGI:3640970
Synonyms: IP3R2-, IP3R2 KO
Gene: Itpr2  Location: Chr6:146108299-146502223 bp, - strand  Genetic Position: Chr6, 77.7 cM
Germline Transmission:  Earliest citation of germline transmission: J:110271
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsMice carrying the floxed allele were crossed with protamine-cre mice to obtain doubly heterozygous for the floxed allele and the protamine-cre allele. These mice were crossed to generate germline heterozgous offspring for generation of Itpr2-null animals. (J:110271)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itpr2 Mutation:  9 strains or lines available
Original:  J:110271 Li X, et al., Endothelin-1-induced arrhythmogenic Ca2+ signaling is abolished in atrial myocytes of inositol-1,4,5-trisphosphate(IP3)-receptor type 2-deficient mice. Circ Res. 2005 Jun 24;96(12):1274-81
All:  48 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory