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Chemically induced Allele Detail
Symbol: Ptk7chz
Name: PTK7 protein tyrosine kinase 7; chuzhoi
MGI ID: MGI:3640803
Gene: Ptk7  Location: Chr17:46564451-46629504 bp, - strand  Genetic Position: Chr17, 22.9 cM, cytoband B3
Ptk7chz/Ptk7chz mice exhibit multiple developmental abnormalities

Show the 8 phenotype image(s) involving this allele.

Strain of Origin:  BALB/cAnN
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsA single nucleotide substitution at the 3' end of Ptk7 intron nine (1475-10 A > G). This intron is of the GT-AG subtype, and the mutation creates a splice acceptor site with closer similarity to the consensus sequence than the wild-type. The new splice acceptor site results in a nine nucleotide insertion in the transcript which add the three amino acids alanine-asparagine-proline into the protein, after the fifth IG-like domain. (J:145068, J:163834)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 28 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptk7 Mutation:  41 strains or lines available
Original:  J:163834 Paudyal A, et al., The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear. BMC Dev Biol. 2010;10:87
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.08
The Jackson Laboratory