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Resttm1And
Targeted Allele Detail
Nomenclature
Symbol: Resttm1And
Name: RE1-silencing transcription factor; targeted mutation 1, David J Anderson
MGI ID: MGI:3640355
Synonyms: Rest-, RestdeltaN
Gene: Rest  Location: Chr5:77265491-77286432 bp, + strand  Genetic Position: Chr5, 41.61 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:50169
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced the ATG and the sequence encoding the first four zinc fingers. Western blot failed to detect protein in mutant ES cells. (J:50169)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rest Mutation:  67 strains or lines available
References
Original:  J:50169 Chen ZF, et al., NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis [see comments]. Nat Genet. 1998 Oct;20(2):136-42
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/20/2017
MGI 6.10
The Jackson Laboratory