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Targeted Allele Detail
Symbol: Csn3tm1Kuma
Name: casein kappa; targeted mutation 1, Satish Kumar
MGI ID: MGI:3640309
Gene: Csn3  Location: Chr5:87925579-87932550 bp, + strand  Genetic Position: Chr5, 43.56 cM
Germline Transmission:  Earliest citation of germline transmission: J:110223
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 3.3 kb fragment including exon 1 and the 5' upstream region was replaced via homologous recombination with a loxP site, partial Hprt gene and neomycin gene. Northern blot analysis did not detect any mRNA; however, expression of other casein genes is similar to wild-type. (J:110223)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Csn3 Mutation:  2 strains or lines available
Original:  J:110223 Shekar PC, et al., kappa-casein-deficient mice fail to lactate. Proc Natl Acad Sci U S A. 2006 May 23;103(21):8000-5
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory