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Org2LG/J
QTL Variant Detail
Summary
QTL variant: Org2LG/J
Name: organ weight 2; LG/J
MGI ID: MGI:3639943
QTL: Org2  Location: unknown  Genetic Position: Chr3, cM position of peak correlated region/allele: 43.71 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  LG/J
Variant
description
Allele Type:    QTL
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:109795

Genetic loci associated with long bone length, necropsy body weight, and organ weight were mapped in 1045 animals from a (LG/J x SM/J)F2 intercross. Animals were phenotyped between 70 and 237 days of age, with an average age at sacrifice of 144 days. Twodifferent sets of F2 mice were genotyped for 75 and 96 polymorphic markers across 19 autosomes. 97 single trait QTL were identified. After pleiotropy analysis the 97 loci coalesced into 35 pleiotropic QTLs. Cutoff for statistical significance is LPR=3.49but all pleiotropic loci listed in the reference are reported here.

On mouse Chromosome 3, linkage to long bone measurements, Lbn3 (long bones 3), mapped to 33.7 cM near D3Mit22 (LPR=6.67). The confidence interval spans 42 cM - 56 cM. Potential candidate genes mapping near Lbn3 include Ptx3 (33.8 cM), Mlf1 (31 cM), and Shox2 (31.6 cM).

Linkage to spleen weight, Org2 (organ weight 2), was detected at 49 cM near D3Mit12 (LPR=3.49). The Org2 confidence interval spans 40 cM - 78 cM.

References
Original:  J:109795 Kenney-Hunt JP, et al., Quantitative trait loci for body size components in mice. Mamm Genome. 2006 Jun;17(6):526-37
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory