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Transgene Detail
Symbol: Tg(tetO-APPSwInd)885Dbo
Name: transgene insertion 885, David R Borchelt
MGI ID: MGI:3639702
Synonyms: TetAPPswe/ind line 885, Tg(tetO-APP*Swe*Ind)885Dbo
Transgene: Tg(tetO-APPSwInd)885Dbo  Location: unknown  
Strain of Origin:  (C57BL/6J x C3H/HeJ)F2
Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
Mutation:    Insertion
Tg(tetO-APPSwInd)885Dbo expresses 1 gene
Mutation detailsThe transgene expresses the mutant human amyloid protein precursor APPSwInd, which bears both the Swedish (K670N/M671L) and the Indiana (V717F) mutations, under the control of the tetracycline-responsive element (tetO). When bred to another transgenic mouse expressing reverse tertracyclin-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (fTA) to creat a bitransgenic animal, tissue APPSwInd transgene expression can be regulated with the tetracycline analog, doxycycline. These double transgenic show the highest APPSwInd expression and have the highest doxycycline requirements for suppression of transgene expression. (J:80782, J:109829)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Founder line 8-85 is the highest expressing line, and is representative of a number of lines made with this construct.
Original:  J:109829 Jankowsky JL, et al., Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease. PLoS Med. 2005 Dec;2(12):e355
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory